Vaccination Strategies in Tauopathies and Synucleinopathies.

Vaccination therapies constitute potential treatment options in neurodegenerative disorders such as Alzheimer disease or Parkinson disease. While a lot of research has been performed on vaccination against extracellular amyloid beta, the focus recently shifted toward vaccination against the intracellular proteins tau and alpha-synuclein, with promising results in terms of protein accumulation reduction. In this review, we briefly summarize lessons to be learned from clinical vaccination trials in Alzheimer disease that target amyloid beta . We then focus on tau and alpha-synuclein. For both proteins, we provide important data on protein immunogenicity, and put them into context with data available from both animals and human vaccination trials targeted at tau and alpha-synuclein. Together, we give a comprehensive overview about current clinical data, and discuss associated problems.