Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Biology of Blood and Marrow Transplantation(2018)
摘要
•Adjuvant cytomegalovirus (CMV) peptide dendritic cell (DC) vaccination in addition to donor-derived CMV peptide-specific T cell infusion appears to be feasible.•No immediate adverse reactions were noted on DC vaccination or T cell infusion.•One of 4 patients developed grade III acute graft-versus-host disease after DC vaccination and T cell infusion.•All patients who received DC vaccination and CMV-specific T cell infusion demonstrated immune reconstitution against CMV.
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关键词
Dendritic cell vaccine,Immunotherapy,Cytomegalovirus,Donor lymphocytes
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