Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients

Biology of Blood and Marrow Transplantation(2018)

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摘要
•Adjuvant cytomegalovirus (CMV) peptide dendritic cell (DC) vaccination in addition to donor-derived CMV peptide-specific T cell infusion appears to be feasible.•No immediate adverse reactions were noted on DC vaccination or T cell infusion.•One of 4 patients developed grade III acute graft-versus-host disease after DC vaccination and T cell infusion.•All patients who received DC vaccination and CMV-specific T cell infusion demonstrated immune reconstitution against CMV.
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关键词
Dendritic cell vaccine,Immunotherapy,Cytomegalovirus,Donor lymphocytes
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