Effect-based approach for screening of chemical mixtures in whole blood of green turtles from the Great Barrier Reef.

•QuEChERS-extraction of blood is suitable for effect-based chemical mixture screening.•This approach was applied to sea turtles from agricultural, urban and remote areas.•Chemical mixture exposure differed significantly in turtles from different areas.•Turtles from the agricultural area showed higher induction in three in vitro assays.•Effect-based in vitro screening can help elucidate internal mixture exposure.