MicroRNA-21 promotes bone mesenchymal stem cells migration in vitro by activating PI3K/Akt/MMPs pathway

Chen Lv,Shengwu Yang,Xin Chen,Xiongbai Zhu,Wenjun Lin,Lu Wang,Zhengxiang Huang, Mingyue Wang,Guanjun Tu

Journal of Clinical Neuroscience（2017）

引用 20|浏览14

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摘要

•miR-21 contributes to the migration of BMSCs.•miR-21 up-regulates MMPs expression in BMSCs.•miR-21 contributes BMSCs migration via PI3K/Akt pathway.•LY294002 can abolish the promote migration effect.

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关键词

MicroRNA-21,MMPs,p-Akt,Bone marrow stem cells,Migration

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