The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J Emmerson, Feng Wang, Yong Du,Qian Liu,Richard T Pickard,Malgorzata D Gonciarz,Tamer Coskun,Matthew J Hamang,Dana K Sindelar, Kimberly K Ballman, Lisa A Foltz, Avinash Muppidi,Jorge Alsina-Fernandez,Gavin C Barnard,Jason X Tang, Xilin Liu, Xudong Mao,Robert Siegel,John H Sloan,Pamela J Mitchell,Bei B Zhang,Ruth E Gimeno, Bei Shan,Xinle Wu

NATURE MEDICINE（2017）

引用 402|浏览55

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摘要

GDF15 has potent anti-obesity effects, but its receptor was previously unknown. GFRAL has now been identified as the receptor for GDF15, and it mediates the effects of GDF15 via central actions in the hindbrain.

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关键词

Blood proteins,Metabolic diseases,Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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