Sorafenib stimulates human skin type mast cell degranulation and maturation

Yukari Mizukami,Koji Sugawara,Yukimi Kira,Daisuke Tsuruta

Journal of Dermatological Science（2017）

引用 9|浏览9

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摘要

•Sorafenib stimulates skin-type mast cell maturation and induces degranulation.•Sorafenib also increases SCF expression within the epidermis.•The effect of sorafenib on mast cell maturation is mediated via PI3K signaling.•PI3K mediated signaling or SCF could be a new target for sorafenib-induced itch.

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关键词

AD,BSA,CRH,ERK,HCC,HFs,Hprt1,MAPK,MC,PBS,MEK,PDGFR,PI3K,RT-PCR,SCF,TUNEL,VEGFR

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