A single-scan protocol for absolute D receptor quantification with [I]IBZM SPECT.

•Research suggests dissociative changes in Bavail and appKd of neuroreceptors.•Currently these parameters are jointly estimated as binding potential (BP).•A single-scan non-invasive protocol for separate estimation is proposed.•Sufficient sensitivity for biological studies is validated.•Endogenous transmitter level assessed through appKd estimation.