Therapy Management Patient Consensus (Themapac): A Patient Perspective On Published Therapy Management Recommendations For Tki-Treated Patients With A Special Focus On Sunitinib

e19502 Background: Therapy management is an essential component of patient care for RCC or GIST patients (pts) treated with TKI (e.g. Sunitinib). Preventive measures and early intervention can reduce or eliminate specific adverse events (AE) allowing for adequate therapy duration and improved quality of life. Published recommendations (RECs) for AE management often rely on theoretical aspects and limited evidence leading to heterogeneous or contradicting RECs. To overcome these issues, a collaborative approach of physicians, pts and Pfizer was established. Here we report on an extensive survey to deepen the knowledge on the validity and practicability of published RECs in 27 TKI treated pts (20 RCC; 7GIST). Methods: RECs (n = 221) for AE management in pts receiving sunitinib or other VEGFR-targeted TKIs were retrieved from the literature since 2006 (approval of sunitinib). RECs were transferred into a detailed questionnaire (QU) using patient-friendly language. Pts receiving sunitinib assigned one of 5 rating categories to each REC (positive experience (self/others); no information; negative experience (self/others). Results: 47 pts received the QU, 27 (15 female; median age 62 yrs) returned evaluable QUs. The pts have been on sunitinib therapy for a median of 16 months. On average, 49% of RECs received positive ratings; 44% based on individual experience. 20 RECs were rated positively by >80% of pts. The results indicate that patients had the most positive experience with RECs about patient/physician information on AEs, care/protection of feet, skin ointment use, food preference, hydration and fatigue reduction. Other REC ratings were heterogeneous, with a preference for measures that can be easily applied in daily life. It is notable that 47% of published RECs were unknown to the participants. Conclusions: To our knowledge, this is the first extensive patient survey on the validity and practicability of published RECs. The results identify a number of useful, established RECs from a real-life pts perspective. The results will be further evaluated and compared with an ongoing physician survey.