Human immune system mouse models of Ebola virus infection.

•Human immune system mice are useful tools for Ebola virus research.•Human lymphoid and myeloid immune cells are reconstituted in human immune system mice.•Wild-type Ebola virus causes disease in humanized mice.•Disease outcome varies with model, dose, route, donor, and time post-engraftment.•Knowledge of human immune cell levels and function in each model is key in interpreting studies.