Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant.

We utilize the supramolecular self-assembling peptide of Nap-G(D)F(D)F(D)Y(D)K to construct chemically programmed, self-assembling and self-adjuvant MUC1-based antitumor vaccines. The vaccines, with antigen and adjuvant conjugation through covalent bonds, elicited both humoral and cellular immune responses.