Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities.

•Benzothiazole analogues were synthesized and characterized.•In vitro antimicrobial and antimalarial activities.•Molecules were subjected to DFT and PM6 calculations to explain the antibacterial activity.•In silico molecular docking and in vitro DHFR inhibiting assay.