Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA 6

Reiya Taniguchi,Asuka Inoue,Misa Sayama,Akiharu Uwamizu,Keitaro Yamashita,Kunio Hirata,Masahito Yoshida,Yoshiki Tanaka,Hideaki E. Kato,Yoshiko Nakada-Nakura,Yuko Otani,Tomohiro Nishizawa,Takayuki Doi,Tomohiko Ohwada,Ryuichiro Ishitani,Junken Aoki,Osamu Nureki

NATURE（2017）

引用 118|浏览31

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摘要

Determination of the crystal structure of the zebrafish LPA 6 receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.

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关键词

G protein-coupled receptors,Lipid signalling,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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