Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Thomas Ve,Parimala R Vajjhala,Andrew Hedger,Tristan Croll,Frank DiMaio,Shane Horsefield,Xiong Yu,Peter Lavrencic, Zahid Hassan,Garry P Morgan,Ashley Mansell,Mehdi Mobli,Ailis O'Carroll,Brieuc Chauvin,Yann Gambin,Emma Sierecki,Michael J Landsberg,Katryn J Stacey,Edward H Egelman,Bostjan Kobe

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

Structural insight into TIR-domain interactions, which are essential for the recruitment of signaling adapters to Toll-like receptors during innate immune responses, demonstrates a conserved interaction mode involved in both TLR and IL-1R signaling.

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关键词

Cell signalling,Cryoelectron microscopy,Immunology,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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