Calreticulin as a novel B cell receptor antigen in chronic lymphocytic leukemia.

Elisa ten Hacken,Maria Gounari,Jaap Willem Back, Ekaterina Shimanovskaya,Lydia Scarfò,Ekaterina Kim, Jared Burks,Maurilio Ponzoni,Giuseppe Alvise Ramirez,William G Wierda,Zeev Estrov,Michael J Keating,Alessandra Ferrajoli,Kostas Stamatopoulos,Paolo Ghia,Jan A Burger

HAEMATOLOGICA（2017）

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摘要

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature monoclonal B lymphocytes with a distinct immune-phenotype (CD19+CD5+CD23+), and a markedly heterogeneous clinical course, ranging from indolent disease to more aggressive presentations. B-cell receptor (BCR) signaling

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关键词

Antigen,B cell receptor,Chronic Lymphocytic Leukemia

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