Incidence, predictors and outcomes of acute-on-chronic liver failure in outpatients with cirrhosis.

•ACLF is common in outpatients with cirrhosis and is associated with a high short-term mortality.•Anemia, hypotension, ascites and MELD score are predictors of ACLF at 12months in these patients.•These variables may identify patients at high risk of developing ACLF enabling strategies of surveillance and prevention to be planned.•Anemia is a potential novel target for strategies of prevention of ACLF.