Development of a LC-MS/MS method for the determination of CKD-712 in rat plasma: Application to a pharmacokinetic study in rats.

Jung-Woo Chae,Hwi-Yeol Yun,Han Young Eom,Eun Ju Jeong,Tae-Sung Koo,Kwang-Il Kwon,Jong-Hwa Lee

Journal of Chromatography B（2017）

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摘要

•CKD-712 is a drug candidate on stage of clinical trial for the treatment of sepsis.•LC–MS/MS assay for determining CKD-712 levels in rat plasma was established and validated.•This method is the simple preparation procedure, which results in adequate recovery.

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关键词

CKD-712,Pharmacokinetics,LC/MS/MS,Rat plasma,Method validation

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