Estimation of individual axon bundle properties by a Multi-Resolution Discrete-Search method.

•We present a method for the estimation of the intra-voxel bundle-wise diffusion properties for DW-MRI.•Our method overcomes some limitations of most multi-fiber algorithms and extends them to estimate the diffusion profiles.•Our method constraints the sparsity of the axon bundles and uses their spatial redundancy to achieve robustness against noise.•We propose a new evaluation metric and a novel methodology for the quantitative evaluation of the methods on in-vivo data.•We present an extensive evaluation on state-of-the-art biophysical synthetic data and on the in-vivo MASSIVE dataset.