An excited state underlies gene regulation of a transcriptional riboswitch
NATURE CHEMICAL BIOLOGY（2017）
Abstract
The use of chemical exchange saturation transfer NMR reveals a previously hidden excited conformational state of the fluoride riboswitch, providing a model in which ligand binding allosterically suppresses a linchpin base pair to activate transcription.
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Key words
NMR spectroscopy,Riboswitches,RNA,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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