Role for loss of nuclear PTEN in a harbinger of brain metastases.

Ryo Nosaka,Fumiyuki Yamasaki,Taiichi Saito,Takeshi Takayasu,Manish Kolakshyapati,Vishwa Jeet Amatya,Yukio Takeshima,Kazuhiko Sugiyama,Kaoru Kurisu

Journal of Clinical Neuroscience（2017）

引用 7|浏览24

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摘要

•The subcellular localization of PTEN in brain metastasis and primary cancers was examined.•PTEN expression levels in brain metastases are lower compared with that of primary site.•Nuclear PTEN expression was significantly downregulated in various brain metastases.•PDK1 expression was inversely associated with PTEN expression.

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关键词

Brain metastasis,PTEN,Subcellular localization,PDK1

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