Connexin43, but not connexin30, contributes to adult neurogenesis in the dentate gyrus.

Jiong Zhang,Stephanie Griemsmann,Zhou Wu,Radoslaw Dobrowolski,Klaus Willecke,Martin Theis,Christian Steinhäuser,Peter Bedner

Brain Research Bulletin（2018）

引用 12|浏览31

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摘要

•Adult neurogenesis in the dentate gyrus requires Cx43 but not Cx30.•The point mutation Cx43G138R entails uncoupling of astrocytes and RG-like cells.•The point mutation reduces proliferation and neurogenesis in the adult dentate gyrus.•Cx43 influences neurogenesis through channel-dependent functions.

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关键词

ACSF,AMPA,β-Gal,BrdU,CA1,Cx,DG,eGFP,GABA,GCL,GFAP,PBS,PFA,RG-like,RT,SGZ,so,sp,sr,SR101,SVZ,WT,ZO-1

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