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Sevoflurane suppresses microglial M2 polarization.

Zengyang Pei,Shenghao Wang,Qi Li

Neuroscience Letters（2017）

Cited 28|Views8
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Abstract
•Sevoflurane abolishes M2 marker genes and proteins expression Arg1, Ym1, and IL-10.•Sevoflurane inhibits the induction of SOCS1 in primary microglia.•Sevoflurane restored the reduction of SOCS3 in primary microglia.•Sevoflurane suppresses the activation of Stat-6.•The suppression of M2 marker genes by sevoflurane is reversible.
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Key words
Microglia,M2 polarization,Sevoflurane,STAT6
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