Bidirectional Brain-Gut Interactions and Chronic Pathological Changes after Traumatic Brain Injury in Mice.

Elise L Ma,Allen D Smith,Neemesh Desai,Lumei Cheung,Marie Hanscom,Bogdan A Stoica,David J Loane,Terez Shea-Donohue,Alan I Faden

Brain, Behavior, and Immunity（2017）

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摘要

•Experimental TBI induces chronic structural and functional changes in the colon.•Barrier dysfunction after TBI is linked to decreased colonic claudin-1 expression.•TBI alters the number of activated enteric glial cells in the colon mucosa.•Enteric C. rodentium infection weeks after TBI exacerbates brain neuropathology.

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关键词

Traumatic brain injury,Mucosal barrier function,Enteric glial cells,Brain-gut axis,Neuroinflammation,Neurodegeneration,Citrobacter rodentium

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