FUNCTIONAL INTERPLAY BETWEEN SECRETED LIGANDS AND RECEPTORS IN MELANOMA.

•Hypomorphic MC1R signaling impairs photoprotection and increases melanoma risk.•Major melanoma driver genes are effectors of receptor tyrosine kinase (RTK) signaling.•Aberrant RTK signaling often contributes to progression and resistance to therapies.•In melanoma, TGFB, IL8 and VEGF are major players in angiogenesis and invasion.•Melanoma-derived exosomes actively contribute to prepare the pre-metastatic niche.