Multivariate analysis of the immune response to a vaccine as an alternative to the repetition of animal challenge studies for vaccines with demonstrated efficacy.

Ludivine Chapat, Florence Hilaire,Jérome Bouvet,Daniel Pialot,Corinne Philippe-Reversat,Anne-Laure Guiot, Lydie Remolue, Jacques Lechenet,Christine Andreoni,Hervé Poulet,Michael J Day,Karelle De Luca,Carine Cariou,Lionel Cupillard

Veterinary Immunology and Immunopathology（2017）

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摘要

•New immunological tools were developed to assess rabies vaccine immunogenicity in dogs.•Multivariate statistical analysis of the immune response to assess minor modifications to antigens when developing new combination vaccines.•Reduce the number of animals to assess the compatibility of vaccines with immunological readout of efficacy as an alternative (3 R’s policy).

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关键词

Rabies vaccine,RABISIN®,Immune fingerprint,Principle component analysis,3Rs

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