Pep-1 peptide-functionalized liposome to enhance the anticancer efficacy of cilengitide in glioma treatment.
Colloids and Surfaces B: Biointerfaces(2017)
摘要
•Glioma tissue penetrating nanocarrier system was developed by conjugating Pep-1 as a targeting ligand.•Conjugation of Pep-1 on the liposome surface remarkably increased the cellular uptake.•PeCNL exhibited a significantly higher cytotoxic effect in cancer cells.•PeCNL exhibited better antitumor efficacy IL-13R2 receptor overexpressed glioma.
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关键词
Glioma,Cilengitide,Liposome,Apoptosis,Nanomedicine
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