Activating transcription factor 3 protects mice against pseudomonas aeruginosa-induced acute lung injury by interacting with lipopolysaccharide binding protein.

Yunfeng Zhao,Xiulin Wu,Lanlan Qian,Liang Guo,Jiangrong Liao,Xueling Wu

Molecular Immunology（2017）

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摘要

•ATF3 have a protective effect in ALI mice induced by PA.•ATF3 weakened the activity of NF-κB through binding to LBP which inhibited the inflammation.•The mechanism for ATF3 in inflammation is proposed.

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关键词

ALI,ATF3,PA,KO,WT,BALF,IL,TNF,NFκa,Co-ip,TLR4,LPS,LBP,ROS,HDL,qRT-PCR,ELISA,μL

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