Pkmyt1 Promoted the Growth and Motility of Hepatocellular Carcinoma Cells by Activating Beta-Catenin/Tcf Signaling
Experimental cell research(2017)
摘要
Over -activation of beta-catenin/TCF signaling has been frequently observed in hepatocellular carcinoma (HCC). Better understanding the molecular mechanism for the aberrant activation of beta-catenin/TCF signaling would provide novel insights into the treatment of this malignancy. In this study, we have shown that the expression of PKMYT1 was up-regulated in HCC. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition (EMT) of HCC cells. Mechanically, PKMTY1 activated the beta-catenin/TCF signaling by binding and inactivating GSK3beta. Taken together, our study demonstrated the oncogenic activity of PKMYT1 in the progression of HCC and suggested that PKMYT1 might be a therapeutic target.
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关键词
Hepatocellular carcinoma,PKMYT1,Beta-catenin/TCF,Epithelial mesenchymal transition
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