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Germline Chd8 haploinsufficiency alters brain development in mouse

Andrea L Gompers,Linda Su-Feher,Jacob Ellegood,Nycole A Copping,M Asrafuzzaman Riyadh,Tyler W Stradleigh,Michael C Pride,Melanie D Schaffler,A Ayanna Wade,Rinaldo Catta-Preta,Iva Zdilar,Shreya Louis,Gaurav Kaushik,Brandon J Mannion,Ingrid Plajzer-Frick,Veena Afzal,Axel Visel,Len A Pennacchio,Diane E Dickel,Jason P Lerch,Jacqueline N Crawley,Konstantinos S Zarbalis,Jill L Silverman,Alex S Nord

NATURE NEUROSCIENCE（2017）

Cited 166|Views19
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Abstract
Strong genetic evidence points to a significant role for heterozygous mutations to general chromatin remodeling factors, such as CHD8, in autism. Gompers et al . combine genomic, neuroanatomical and behavioral approaches to present an initial integrative picture of transcriptional mechanisms and widespread impacts of Chd8 haploinsufficiency across brain development in mice.
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Key words
Functional genomics,Autism spectrum disorders,Neuronal development
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