Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors.

Sucharita S Somkuwar,Leandro F Vendruscolo,McKenzie J Fannon,Brooke E Schmeichel,Tran Bao Nguyen,Jasmin Guevara,Harpreet Sidhu,Candice Contet,Eric P Zorrilla,Chitra D Mandyam

Psychoneuroendocrinology（2017）

引用 59|浏览14

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摘要

•Chronic ethanol enhances peak CORT and does not alter nadir CORT.•Acute withdrawal from chronic ethanol enhances irritability-like behavior.•Withdrawal and abstinence from chronic ethanol alters GR signaling in the mPFC.•Systemic mifepristone prevents withdrawal-induced alterations in GR signaling in the mPFC.

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关键词

Corticosterone,Glucocorticoid receptor,Aggression,Anxiety,Abstinence,Medial prefrontal cortex

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