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Cryo-soft X-ray tomography as a quantitative three-dimensional tool to model nanoparticle:cell interaction

Michele Chiappi,José Javier Conesa,Eva Pereiro,Carlos Oscar Sánchez Sorzano,María Josefa Rodríguez,Katja Henzler,Gerd Schneider,Francisco Javier Chichón,José L. Carrascosa

Journal of Nanobiotechnology（2016）

Cited 47|Views6
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Abstract
Recent advances in nanoparticle design have generated new possibilities for nano-biotechnology and nano-medicine. Here we used cryo-soft X-ray tomography (cryo-SXT) to collect comprehensive three-dimensional (3D) data to characterise the interaction of superparamagnetic iron oxide nanoparticles (SPION) with a breast cancer cell line.
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Key words
Cryo-soft X-ray tomography,SPION,Cancer cell lines,Hyperthermia,Endocytic pathways
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