Immunomodulation with thymopentin:in vitro studies
Medical Oncology and Tumor Pharmacotherapy(1989)
摘要
Immunomodulation is interpreted as a temporary alert in a certain part of the immune system. The activation of immune competent
cells is presented as a possible basic mechanism of this phenomenon. In the absence of a primary stimulus, immunomodulation
remains physiologically silent, but it results in a modified immune response if the corresponcling targets are being stimulated.
For practical reasons it is suggested that distinctions be made between preventive and regulative immunomodulation.
The PWM-induced IgG production of PBMCs was used as a model for the demonstration of the modulatory effect of thymopentinin vitro. Depencling on the concentration of thymopentin used in the cultures, this pentapeptide can either stimulate or inhibit the
induced IgG production. It also influences PGE2 production and catabolism in the cultures stimulated with PWM. Indomethacin abolishes the modulatory effect of thymopentin
on IgG production in this model. It is suggested that the possibility of interactions between an immune modulator and therapeutic
approaches which can influence the proportions or functions of the corresponcling target cells be considered.
更多查看译文
关键词
Immunomodulation, Thymopentin, Thymic hormone, IgG secretion, In vitro, Pokeweed mitogen stimulation, PGE2 catabolism, PGE2 productionin vitro, Peripheral blood mononuclear cells
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要