Total Synthesis of the Diterpenoid (+)-Harringtonolide

Described herein is the first asymmetric total synthesis of (+)-harringtonolide, a natural diterpenoid with an unusual tropone imbedded in a cagelike framework. The key transformations include an intramolecular Diels__lder reaction and a rhodium-complex-catalyzed intramolecular [3+2] cycloaddition to install the tetracyclic core as well as a highly efficient tropone formation. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim