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Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Benjamin Mordmüller,Güzin Surat,Heimo Lagler,Sumana Chakravarty,Andrew S. Ishizuka,Albert Lalremruata,Markus Gmeiner,Joseph J. Campo,Meral Esen,Adam J. Ruben,Jana Held,Carlos Lamsfus Calle,Juliana B. Mengue,Tamirat Gebru,Javier Ibáñez,Mihály Sulyok,Eric R. James,Peter F. Billingsley,KC Natasha,Anita Manoj,Tooba Murshedkar,Anusha Gunasekera,Abraham G. Eappen,Tao Li,Richard E. Stafford,Minglin Li,Phil L. Felgner,Robert A. Seder,Thomas L. Richie,B. Kim Lee Sim,Stephen L. Hoffman,Peter G. Kremsner

NATURE（2017）

Cited 413|Views26
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Abstract
Immunization with Plasmodium falciparum sporozoites under chemoprophylaxis can protect against controlled human malaria infection with the same strain for at least 10 weeks, and protection correlates with polyfunctional T-cell memory.
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Key words
Malaria,Live attenuated vaccines
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