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Transcriptional programs that control expression of the autoimmune regulator gene Aire

Yonatan Herzig,Shir Nevo,Chamutal Bornstein, Miriam R Brezis,Sharon Ben-Hur,Aya Shkedy,Michal Eisenberg-Bord,Ben Levi,Michael Delacher,Yael Goldfarb,Eyal David,Leehee Weinberger,Sergey Viukov,Shifra Ben-Dor,Matthieu Giraud,Jacob H Hanna,Achim Breiling,Frank Lyko,Ido Amit,Markus Feuerer,Jakub Abramson

NATURE IMMUNOLOGY（2016）

Cited 45|Views16
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Abstract
mson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions in the locus encoding the transcriptional regulator Aire to control its expression.
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Key words
Gene regulation in immune cells,Autoimmunity
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