LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

Kaloyan M. Tsanov,Daniel S. Pearson,Zhaoting Wu,Areum Han,Robinson Triboulet,Marc T. Seligson,John T. Powers,Jihan K. Osborne,Susan Kane,Steven P. Gygi,Richard I. Gregory,George Q. Daley

Nature Cell Biology（2016）

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摘要

Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability and effects of LIN28 on direct mRNA targets through its phosphorylation by ERK.

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关键词

Embryonic stem cells,Phosphorylation,Pluripotency,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells

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