Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

David Stucki,Daniela Brites, Leïla Jeljeli,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Lukas Fenner,Liliana Rutaihwa,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno, Griselda Tudo Vilanova,Janet Fyfe,Maria Globan,Jackson Thomas,Frances Jamieson,Jennifer L Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie Wampande,Willy Ssengooba,Moses Joloba,W Henry Boom,Indira Basu,James Bower,Margarida Saraiva,Sidra E G Vasconcellos,Philip Suffys,Anastasia Koch,Robert Wilkinson,Linda Gail-Bekker,Bijaya Malla,Serej D Ley,Hans-Peter Beck,Bouke C de Jong, Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Veronique N Penlap Beng,Kathleen Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux

Nature Genetics（2016）

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摘要

Sebastien Gagneux and colleagues analyze a global collection of Mycobacterium tuberculosis clinical isolates to classify sublineages by phylogeography. They find globally distributed ‘generalist’ and geographically restricted ‘specialist’ sublineages of lineage 4, indicating that different evolutionary strategies were adopted to succeed in various ecological niches.

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关键词

Microbial genetics,Tuberculosis,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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