Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

Sungguan Hong,Wenjun Zhou,Bin Fang,Wenyun Lu,Emanuele Loro,Manashree Damle,Guolian Ding,Jennifer Jager,Sisi Zhang,Yuxiang Zhang,Dan Feng,Qingwei Chu,Brian D Dill,Henrik Molina,Tejvir S Khurana,Joshua D Rabinowitz,Mitchell A Lazar,Zheng Sun

NATURE MEDICINE（2016）

引用 79|浏览11

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摘要

Genetic deletion of HDAC3, a circadian epigenome regulator, specifically in skeletal muscle alters amino acid metabolism, leading to increased muscle endurance but at the cost of whole-body insulin resistance.

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关键词

Metabolism,Type 2 diabetes

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