Single-molecule analysis reveals multi-state folding of a guanine riboswitch

NATURE CHEMICAL BIOLOGY(2016)

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摘要
Single-molecule force spectroscopy and thermodynamics studies reveal six conformational states in the formation of a guanine aptamer, with a ‘kissing loop’ playing a key role in the conformational switching.
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关键词
Structure determination,Nucleic acids,Single-molecule biophysics
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