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SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

Xiaofeng Wang,Ryan S Lee,Burak H Alver,Jeffrey R Haswell,Su Wang,Jakub Mieczkowski,Yotam Drier,Shawn M Gillespie,Tenley C Archer,Jennifer N Wu,Evgeni P Tzvetkov,Emma C Troisi,Scott L Pomeroy,Jaclyn A Biegel,Michael Y Tolstorukov,Bradley E Bernstein,Peter J Park,Charles W M Roberts

NATURE GENETICS（2016）

Cited 239|Views22
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Abstract
Charles Roberts, Peter Park, Bradley Bernstein and colleagues examine the consequences of SMARCB1 loss on enhancer landscapes in human rhabdoid tumors. They show that SMARCB1 is essential for the integrity and abundance of SWI/SNF complexes and facilitates their targeting to appropriate enhancers.
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Key words
Gene regulation,Cancer,Epigenetics
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