Mining Protein Complexes Based On Topology Potential From Weighted Dynamic Ppi Network
2016 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)(2016)
摘要
Identification of protein complexes is very important to investigate the characteristics of biological processes. Most of existing protein complex clustering algorithms were often run only on a static protein-protein interaction (PPI) network. The dynamic characteristics of interactions were ignored. In order to solve the problem, a new clustering algorithm (TP-WDPIN) was proposed which is based on the concept of topological potential to measure the importance of proteins in the process of detecting seed proteins and then to mine protein complexes from weighted dynamic PPI network. The algorithm used features of core-attachment of complexes and split low density cores to improve density of cores for achieving better clustering results. Experiment results showed that the proposed TP-WDPIN algorithm has better performance than other algorithms on two PPI databases.
更多查看译文
关键词
dynamic PPI network, topology potential, core removal, protein complexes
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络