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Expression of mesothelin in thymic carcinoma and its potential therapeutic significance

Anish Thomas,Yuanbin Chen,Arlene Berman,David S. Schrump,Giuseppe Giaccone,Ira Pastan,David J. Venzon,David J. Liewehr,Seth M. Steinberg,Markku Miettinen,Raffit Hassan,Arun Rajan

Lung Cancer（2016）

Cited 16|Views26
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Abstract
•Mesothelin, a cell surface antigen is a target for tumor-directed therapy.•Thymic carcinomas frequently demonstrate strong mesothelin expression.•High mesothelin expression in thymic carcinoma is associated with longer survival.•Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.
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Key words
Thymic carcinoma,Mesothelin,Immunohistochemistry,Therapeutic target,Immunotherapy
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