Polymorphisms in the prostaglandin receptor EP2 gene confers susceptibility to tuberculosis

•Disruption of EP2 expression causes mice to become more susceptible to M. tuberculosis infection.•The rs937337 polymorphism is associated with increased risk to TB.•The rs937337 AA genotype and the rs1042618 CC genotype were significantly associated with TB.•The remaining SNPs of EP2 were nominally associated with clinical patterns of disease.•EP2 SNPs are genetic predispositions of increased susceptibility to TB.