Preparation of oxocene terpenes. The first enantiospecific synthesis of cytotoxic arenaran A
Organic & Biomolecular Chemistry(2016)
摘要
The first syntheses of cytotoxic marine arenarans A and B starting from commercial (-)-sclareol are reported. The oxocene ring of the target compound is formed via ring-closing metathesis, a process that depends on certain structural requirements. The trans-fused structure of the natural product is confirmed by comparison with the cis-fused isomer, which was synthesized. This synthetic strategy is also applicable to the synthesis of other oxocene terpenes.
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关键词
oxocene terpenes,first enantiospecific synthesis
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