Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide.
Leukemia research（2016）
Abstract
•The expression of arsenic transporters, MRP1, MRP2 and ASNA1, correlates negatively with leukemia MDR cells’ ATO-sensitivity.•ATO enhances and inhibits the transporters’ expression in arsenic-resistant and -sensitive leukemia MDR cells, respectively.•The transporters’ expression and response to arsenic stress determine leukemia MDR cells’ ATO-sensitivity.
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Key words
Arsenic-resistance,Multi-drug resistance,MRP1,MRP2,ASNA1,Leukemia cell
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