Methylmercury induces an initial increase in GABA-evoked currents in Xenopus oocytes expressing α1 and α6 subunit-containing GABAA receptors

Tidao Tsai,Yukun Yuan,Ravindra K. Hajela,Shuan W. Philips,William D. Atchison

NeuroToxicology（2017）

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摘要

•The initial effects of methylmercury (MeHg) on IGABA are mediated by α1β2γ2S or α6β2γ2S receptors expressed in Xenopus laevis oocytes.•Bath application of MeHg initially potentiated IGABA to its more defined later effects.•This effect is reversible and appears to be a direct interaction of MeHg with GABAA receptors.

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关键词

Methylmercury,GABAA receptor,α1 and α6 subunit,Heterologous expression

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