A meta-analysis of association between glutathione S-transferase gene polymorphism and osteosarcoma chemosensitivity in Chinese population.

Objective: In this study, a meta-analysis was performed to investigate whether there is an association between glutathione S-transferase (GST) gene polymorphism and chemosensitivity in patients with osteosarcoma. Methods: A comprehensive electronic database search was performed between January 1, 2016, and May 21, 2016. All eligible studies related to GST gene polymorphism and chemosensitivity in patients with osteosarcoma were screened and included in the current meta-analysis. The association between GSTT1, GSTM1 and osteosarcoma chemosensitivity was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot. Results: A total of four studies with 681 osteosarcoma patients were included in the present study. The data were pooled by fixed effect model for lack of statistical heterogeneity. The results showed there was no significant association between GSTT1 OR = 1.04, 95% CI: 0.77u1.41, P 0.05), GSTM1 (OR = 1.08, 95% CI: 0.80u1.46, P 0.05) gene polymorphism and chemosensitivity in patients with osteosarcoma was found by pooled the published data. Begg's funnel plot indicated no significant publication bias in meta-analysis. Conclusion: Glutathione S-transferase gene polymorphism had no association with chemosensitivity in patients with osteosarcoma.