Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

Yunqing Ma,Jiayuan Zhang,Weijie Yin,Zhenchao Zhang,Yan Song,Xing Chang

NATURE METHODS（2016）

引用 274|浏览13

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摘要

Fusing a cytidine deaminase to dCas9 allows for a forward genetic screen in mammalian cells that identifies mutations conferring drug resistance.

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关键词

Adaptive immunity,Functional genomics,Gene targeting,Life Sciences,general,Biological Techniques,Biological Microscopy,Biomedical Engineering/Biotechnology,Bioinformatics,Proteomics

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