Mapping 3D genome architecture through in situ DNase Hi-C

Vijay Ramani,Darren A Cusanovich,Ronald J Hause,Wenxiu Ma,Ruolan Qiu,Xinxian Deng,C Anthony Blau,Christine M Disteche,William S Noble,Jay Shendure,Zhijun Duan

NATURE PROTOCOLS（2016）

引用 86|浏览1

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摘要

Ramani et al . describe a protocol for in situ DNase Hi-C as an alternative to traditional Hi-C methods that use restriction enzymes. The use of DNase I for chromatin digestion circumvents the resolution limit imposed when relying on genomic restriction sites.

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关键词

Parasite biology,High-throughput screening,Isolation,separation and purification,Malaria

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