Genetic backgrounds determine brown remodeling of white fat in rodents.

Giulia Ferrannini,Maria Namwanje,Bin Fang,Manashree Damle,Dylan Li,Qiongming Liu,Mitchell A Lazar,Li Qiang

Molecular Metabolism（2016）

引用 30|浏览13

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摘要

•Rodent genetic background determines the physiological responses to cold.•Genetic background determines browning capacity of white adipose tissue.•The brown remodeling is affected by genetic background in a depot-specific manner.•Hoxc10 is a novel repressor of browning in subcutaneous white adipose tissue.

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关键词

Genetic background,White adipose tissue,Brown remodeling,Hoxc10,Cold exposure,Browning brake

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