Suppressor of cytokine signaling 2 (SOCS2) contributes to encephalitis in a model of Herpes infection in mice.

Larissa Fonseca da Cunha Sousa,Milene Alvarenga Rachid,Graciela Kunrath Lima,Aline Silva de Miranda,Márcia de Carvalho Vilela, Norinne Lacerda Queiroz,David Henrique Rodrigues,Marco Antonio Campos,Erna Geessien Kroon,Fabiana Simão Machado,Antônio Lúcio Teixeira

Brain Research Bulletin（2016）

引用 8|浏览20

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摘要

•HSV-1 infected SOCS2−/− mice had increased survival in comparison with infected WT animals.•Better clinical outcome following HSV-1 infection was associated with reduced neuroinflammation.•SOCS2 plays a detrimental role in HSV-1 encephalitis.

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关键词

HSV-1,Encephalitis,SOCS2,Neuroinflammation

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